دورية
Mitochondrion-processed TERCregulates senescence without affecting telomerase activities
| العنوان: | Mitochondrion-processed TERCregulates senescence without affecting telomerase activities |
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| المؤلفون: | Zheng, Qian, Liu, Peipei, Gao, Ge, Yuan, Jiapei, Wang, Pengfeng, Huang, Jinliang, Xie, Leiming, Lu, Xinping, Di, Fan, Tong, Tanjun, Chen, Jun, Lu, Zhi, Guan, Jisong, Wang, Geng |
| المصدر: | Protein & Cell; September 2019, Vol. 10 Issue: 9 p631-648, 18p |
| مستخلص: | Mitochondrial dysfunctions play major roles in ageing. How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERCis imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc−/−cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals. |
| قاعدة البيانات: | Supplemental Index |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1674800X 16748018 |
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| DOI: | 10.1007/s13238-019-0612-5 |