دورية
Citalopram versus fluoxetine a doubleblind, controlled, multicentre, phase III trial in patients with unipolar major depression treated in general practice
| العنوان: | Citalopram versus fluoxetine a doubleblind, controlled, multicentre, phase III trial in patients with unipolar major depression treated in general practice |
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| المؤلفون: | Patris, M., Bouchard, JM., Bougerol, T., Charbonnier, JF., Chevalier, JF., Clerc, G., Cyran, C., Van Amerongen, P., Lemming, O., Petersen, H. E. Høpfner |
| المصدر: | International Clinical Psychopharmacology; June 1996, Vol. 11 Issue: 2 p129-136, 8p |
| مستخلص: | Two selective serotonin reuptake inhibitors SSRIs, citalopram and fluoxetine, both at a daily dose of 20 mg, were compared in patients with unipolar major depression treated in general practice. This was a multicentre, doubleblind, randomized trial carried out in France. The duration of treatment was 8 weeks. Patients were assessed by means of the Montgomerysberg Depression Rating Scale MADRS, the 17 items Hamilton Depression Rating Scale HAMD and the investigator's Clinical Global Impressions CGI. Observed and spontaneously reported adverse events were also recorded. A total of 357 patients of both sexes, aged between 21 and 73 years, entered the doubleblind phase of the trial. A clear reduction of both the MADRS and the HAMD mean total scores was observed in both treatment groups with no statistically significant differences between treatments. Apart from back pain recorded more frequently in the citalopram group, no significant difference was found between the two treatment groups with regard to adverse events, and both citalopram and fluoxetine were considered to be well tolerated. It was concluded that citalopram was as effective as fluoxetine in the treatment of unipolar major depression. Citalopram showed an earlier onset of recovery than fluoxetine. |
| قاعدة البيانات: | Supplemental Index |
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