دورية
Genetic diversity of Leptospira interroganscirculating isolates and vaccine strains in China from 1954–2014
| العنوان: | Genetic diversity of Leptospira interroganscirculating isolates and vaccine strains in China from 1954–2014 |
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| المؤلفون: | Zhang, Cuicai, Li, Zhe, Xu, Yinghua, Zhang, Ying, Li, Shijun, Zhang, Jinlong, Cui, Shenghui, Du, Zongli, Xin, Xiaofang, Chang, Yung-Fu, Jiang, Xiugao, Ye, Qiang |
| المصدر: | Human Vaccines & Immunotherapeutics; February 2019, Vol. 15 Issue: 2 p381-387, 7p |
| مستخلص: | ABSTRACTLeptospirosis is one of the most important but neglected, infectious tropical diseases worldwide. Leptospira interrogansis now recognized as a leading cause of the disease. Little is known of the genetic diversity and phylogenetic characteristics of L. interroganswithin China. To better understand the transmission and genetic diversity of L. interroganspopulations, we characterized 271 isolates and seven vaccine strains from China during 1954–2014 using multilocus variable-number tandem repeat analysis (MLVA). 110 different L. interrogansMLVA profiles (MTs) were identified, of which five were predominant, reflecting a high level of genetic diversity in L. interroganspopulation in China. Different from that of circulating isolates, seven vaccine strains have different MT, of which some are phylogenetically away from the circulating isolates. The results showed that Icterohaemorrhagiae, Hebdomadis, and Canicola ranked as the top three serogroups among L. interrogansstrains tested. The cluster analysis demonstrate the clonal links between rodent and human isolates, suggesting the rodent species played a key role in the transmission of leptospirosis to humans, and contributed to the circulation of the pathogen in humans. Taken together, these findings should provide insight into a better knowledge of the epidemiology and molecular evolution of L. interrogansin China. Furthermore, the results should facilitate the selection of candidate vaccine strains in the future. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 21645515 2164554X |
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| DOI: | 10.1080/21645515.2018.1528839 |