دورية
Antibacterial and Antiparasitic Effects of Bothropoides lutzivenom
| العنوان: | Antibacterial and Antiparasitic Effects of Bothropoides lutzivenom |
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| المؤلفون: | de Menezes, Ramon R.P.P.B., Torres, Alba F. C., da Silva, Thiala S. J., de Sousa, Daniel F., Lima, Danya B., Norjosa, Dive B., Nogueira, Nádia A. P., Oliveira, Maria F., de Oliveira, Márcia R., Monteiro, Helena S. A., Martins, Alice M. C. |
| المصدر: | Natural Product Communications; January 2012, Vol. 7 Issue: 1 |
| مستخلص: | The therapeutic potential of toxins has aroused great interest in the scientific community. Microbial resistance is a serious current public health problem, in part because of the wide use of antimicrobial drugs. Furthermore, there are several problems in the treatment of parasitic diseases such as leishmaniosis and Chagas’ disease, including the low efficacy in some clinical phases of the diseases and the loss of effectiveness of benzonidazole in the chronic phase of Chagas’ disease. In this context, the aim of this work was to study the antimicrobial and antiparasitic effects of Bothropoides lutzitotal venom (BltTV). The venom exerted an antibacterial effect on S. aureus, with MIC=MLC=200 μg/mL. The inhibitory effects of BltTV on promastigote forms of Leishmania amazonensisand L. chagasiwere assessed by counting of viable cells after incubation with BltTV. IC50values of 234.6 μg/mL and 61.2 μg/mL, were obtained, respectively. Furthermore, the venom repressed epimastigote forms of Trypanosoma cruzigrowth. Finally, BltTV was verified to affect murine peritoneal macrophages, causing a cytotoxic effect at the highest concentrations (100 and 50 μg/mL). In conclusion, Bothropoides lutzivenom demonstrated antibacterial and antiparasite effects, suggesting that the venom contains some substance(s) of therapeutic value. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 1934578X 15559475 |
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| DOI: | 10.1177/1934578X1200700125 |