دورية
Strepantibins A–C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomycessp.
| العنوان: | Strepantibins A–C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomycessp. |
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| المؤلفون: | Song, Ya-Jie, Zheng, Hong-Bo, Peng, Ai-Hong, Ma, Jia-Hui, Lu, Dan-Dan, Li, Xia, Zhang, Hang-Yu, Xie, Wei-Dong |
| المصدر: | Journal of Natural Products; 20240101, Issue: Preprints |
| مستخلص: | Two new p-terphenyls, strepantibins A and B (1and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomycessp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were determined by high-resolution electrospray ionization mass spectrometry, NMR, and X-ray crystallography data interpretation. Strepantibins A–C inhibited hexokinase II (HK2) activity and displayed antiproliferative activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5. In SMMC-7721 cells treated with strepantibin A, the morphological characteristics of apoptosis were observed. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 01633864 15206025 |
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| DOI: | 10.1021/acs.jnatprod.8b00821 |