دورية
Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial
| العنوان: | Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial |
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| المؤلفون: | Mantovani, G., Isidori, A. M., Moretti, C., Di Dato, C., Greco, E., Ciolli, P., Bonomi, M., Petrone, L., Fumarola, A., Campagna, G., Vannucchi, G., Di Sante, S., Pozza, C., Faggiano, A., Lenzi, A., Giannetta, E. |
| المصدر: | Endocrine; December 2019, Vol. 66 Issue: 3 p542-550, 9p |
| مستخلص: | Purpose: Selenium is frequently in nutraceuticals for pregnancy, given its role on fertility and thyroid metabolism. However, most evidence rise from non-controlled studies. We aimed to evaluate the protective effect of selenium against thyroid autoimmunity during and after pregnancy. Methods: A multicenter, randomized, double-blind, placebo-controlled trial was performed and promoted by the Young Italian Endocrinologists Group (EnGioI)—Italian Society of Endocrinology. Forty-five women with thyroiditis in pregnancy were enrolled and randomly assigned to L-selenomethionine (L-Se-Met) 83 mcg/day or placebo (PLB) and evaluated at 10 ± 2 (T1), 36 ± 2 weeks of gestation (T2) and 6 months after delivery (postpartum, PP). Results: We measured a significant reduction of autoantibodies after pregnancy in L-Se-Met group [at PP: TgAb 19.86 (11.59–52.60), p< 0.01; TPOAb 255.00 (79.00–292.00), p< 0.01], and an antibodies titer’s rebound in PLB group (TgAb 151.03 ± 182.9, p< 0.01; TPOAb 441.28 ± 512.18, p< 0.01). A significant increase in selenemia was measured in L-Se-Met group at T2 (91.33 ± 25.49; p< 0.01) and PP (93.55 ± 23.53; p= 0.02). Two miscarriage occurred in PLB. No differences were found in thyroid volume, echogenicity, quality of life, maternal/fetal complications. Conclusions: SERENA study demonstrated a beneficial effect of L-Se-Met supplementation on autoantibody titer during pregnancy and on postpartum thyroiditis recurrence. |
| قاعدة البيانات: | Supplemental Index |
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Full Text Finder | تدمد: | 1355008x 15590100 |
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| DOI: | 10.1007/s12020-019-01958-1 |