دورية
Classical and novel strategies to develop a Shigellaglycoconjugate vaccine: from concept to efficacy in human
| العنوان: | Classical and novel strategies to develop a Shigellaglycoconjugate vaccine: from concept to efficacy in human |
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| المؤلفون: | Barel, Louis-Antoine, Mulard, Laurence A. |
| المصدر: | Human Vaccines & Immunotherapeutics; June 2019, Vol. 15 Issue: 6 p1338-1356, 19p |
| مستخلص: | ABSTRACTShigellaare gram-negative bacteria that cause severe diarrhea and dysentery, with a high level of antimicrobial resistance. Disease-induced protection against reinfection in Shigella-endemic areas provides convincing evidence on the feasibility of a vaccine and on the importance of Shigellalipopolysaccharides as targets of the host humoral protective immune response against disease. This article provides an overview of the original and current strategies toward the development of a Shigellaglycan-protein conjugate vaccine that would cover the most commonly detected strains. Going beyond pioneering “lattice”-type polysaccharide-protein conjugates, progress, and challenges are addressed with focus on promising alternatives, which have reached phases I and II clinical trial. Glycoengineered bioconjugates and “sun”-type conjugates featuring well-defined synthetic carbohydrate antigens are discussed with insights on the molecular parameters governing the rational design of a cost-effective glycoconjugate vaccine efficacious in preventing diseases caused by Shigellain the most at risk populations, young children living in endemic areas. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 21645515 2164554X |
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| DOI: | 10.1080/21645515.2019.1606972 |