دورية
Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells
| العنوان: | Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells |
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| المؤلفون: | Fukami, M H, Haavik, J, Flatmark, T |
| المصدر: | Biochemical Journal; June 1990, Vol. 268 Issue: 2 p525-528, 4p |
| مستخلص: | Incubation of bovine chromaffin cells with L-[14C]phenylalanine resulted in label accumulation in catecholamines at about 30% of the rate seen with L-tyrosine as precursor. Studies with purified tyrosine hydroxylase (EC 1.14.16.2) showed that the enzyme catalysed the hydroxylation of L-phenylalanine first to L-p-tyrosine and then to 3,4-dihydroxyphenylalanine (DOPA). No evidence for a significant involvement of an L-m-tyrosine intermediate in DOPA formation was found. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 02646021 14708728 |
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| DOI: | 10.1042/bj2680525 |