دورية
The effect of insulin-like growth factor II on glucose uptake and metabolism in rat skeletal muscle in vitro
| العنوان: | The effect of insulin-like growth factor II on glucose uptake and metabolism in rat skeletal muscle in vitro |
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| المؤلفون: | Bevan, S J, Parry-Billings, M, Opara, E, Liu, C T, Dunger, D B, Newsholme, E A |
| المصدر: | Biochemical Journal; September 1992, Vol. 286 Issue: 2 p561-565, 5p |
| مستخلص: | The effect of insulin-like growth factor II (IGF II) on the rates of lactate formation, glycogen synthesis and glucose transport in the presence of a range of concentrations of insulin were investigated using an isolated preparation of rat skeletal muscle. IGF II, at a concentration of 65 ng/ml, caused a small but significant increase in the rates of these processes at a basal physiological insulin concentration (10 muunits/ml), but was without effect in the presence of 1, 100, 1000 or 10,000 muunits of insulin/ml. Hence IGF II increased the insulin sensitivity of this tissue. This effect was removed if the incubation medium was supplemented with an equimolar concentration of IGF binding protein 1 (BP1). It is suggested that changes in the concentration of IGF II and/or BP1 may regulate glucose uptake and metabolism in skeletal muscle and have physiological significance in the control of blood glucose level. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 02646021 14708728 |
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| DOI: | 10.1042/bj2860561 |