التفاصيل البيبلوغرافية
| العنوان: |
BF3·OEt2-Catalyzed Vinyl Azide Addition to in Situ Generated N-Acyl Iminium Salts: Synthesis of 3-Oxoisoindoline-1-acetamides |
| المؤلفون: |
Kumar Das, Deb, Kannaujiya, Vinod Kumar, Sadhu, Milon M., Ray, Sumit Kumar, Singh, Vinod K. |
| المصدر: |
The Journal of Organic Chemistry; December 2019, Vol. 84 Issue: 24 p15865-15876, 12p |
| مستخلص: |
BF3·OEt2-catalyzed nucleophilic addition of vinyl azides to in situ generated N-acyl iminium salts obtained from 3-hydroxyisoindolinones is described in this article. The procedure is operationally simple, mild, additive, and metal-free. The reaction proceeds smoothly at ambient temperature with a wide range of 3-hydroxyisoindol-1-ones and vinyl azides to afford 3-oxoisoindoline-1-acetamides (32 examples) in high yields (up to 97%). Furthermore, the synthetic utility of this methodology is depicted by exploiting the reactivity of an amide functionality in the products. |
| قاعدة البيانات: |
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