التفاصيل البيبلوغرافية
| العنوان: |
Tunable Synthesis of α-Amino Boronic Esters from Available Aldehydes and Amines through Sequential One-Pot Dehydration and Copper-Catalyzed Borylacylation |
| المؤلفون: |
Xia, Qi, Chang, Hua-Rong, Li, Juan, Wang, Jia-Yi, Peng, Yan-Qing, Song, Gong-Hua |
| المصدر: |
The Journal of Organic Chemistry; February 2020, Vol. 85 Issue: 4 p2716-2724, 9p |
| مستخلص: |
Copper-catalyzed multicomponent borylacylation of imines with acid chlorides and bis(pinacolato)diboron was developed for the preparation of synthetically useful and pharmacologically relevant α-amino boronic acid derivatives. Starting from a range of acid chlorides and imines with aryl, heteroaryl, and alkyl substituents, most of these ligand-free reactions proceeded smoothly at room temperature in moderate to good yields. Furthermore, a facile and convenient one-pot, multistep access to the direct synthesis of α-amino boronic acid derivatives from available aldehydes and amines was also developed. |
| قاعدة البيانات: |
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