دورية
Discovery of isoxazolyl-based inhibitors of Plasmodium falciparumcGMP-dependent protein kinaseElectronic supplementary information (ESI) available: General procedures and compound characterization is available. NMR and mass spectral data on all tested compounds as well as general synthetic procedures and biological evaluation. See DOI: 10.1039/c9md00511k
| العنوان: | Discovery of isoxazolyl-based inhibitors of Plasmodium falciparumcGMP-dependent protein kinaseElectronic supplementary information (ESI) available: General procedures and compound characterization is available. NMR and mass spectral data on all tested compounds as well as general synthetic procedures and biological evaluation. See DOI: 10.1039/c9md00511k |
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| المؤلفون: | Mahmood, Shams Ul, Cheng, Huimin, Tummalapalli, Sreedhar R., Chakrasali, Ramappa, Yadav Bheemanaboina, Rammohan R., Kreiss, Tamara, Chojnowski, Agnieska, Eck, Tyler, Siekierka, John J., Rotella, David P. |
| المصدر: | MedChemComm; 2020, Vol. 11 Issue: 1 p98-101, 4p |
| مستخلص: | The cGMP-dependent protein kinase in Plasmodium falciparum(PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 20402503 20402511 |
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| DOI: | 10.1039/c9md00511k |