التفاصيل البيبلوغرافية
| العنوان: |
Links between SNPs in TLR-2and TLR-4and idiopathic recurrent pregnancy loss |
| المؤلفون: |
Bahia, W, Soltani, I, Haddad, A, Radhouani, A, Mahdhi, Abdelkarim, Ferchichi, S, Almawi, WY |
| المصدر: |
British Journal of Biomedical Science; April 2020, Vol. 77 Issue: 2 p64-68, 5p |
| مستخلص: |
ABSTRACTBackground: Recurrent pregnancy loss is a serious complication of pregnancy and failure of the innate immune system, one part of which are toll-like receptors (TLRs). We hypothesised links between variants of TLR-2and TLR-4with recurrent pregnancy loss.Subjects and methods: We recruited 335 women with recurrent pregnancy loss, defined as ≥3 consecutive spontaneous miscarriage of unknown aetiology, and 331 age-matched control women. TLR-2rs1898830 and rs4696483 and TLR-4rs2770150, rs1554973 and rs7856729 genotyping were performed by allelic exclusion method (real-time PCR).Result: Of the five tested TLR-2and TLR-4tag-SNPs, minor allele frequency of TLR-2rs1898830 was significantly more frequent in recurrent pregnancy loss patients than in controls. Significantly higher frequencies of homozygous (2/2) TLR-2rs1898830 (14.1% vs. 8.9%) genotype carriers were seen between recurrent pregnancy loss cases and control women. Haploview analysis identified 1-locus TLR-2haplotype (GC) that was positively associated with recurrent pregnancy loss. No TLR-4haplotypes associated with altered recurrent pregnancy loss risk were identified.Conclusion: These findings confirm positive associations of TLR-2rs1898830 with recurrent pregnancy loss, further supporting a role for TLR signalling in defining pregnancy outcome. |
| قاعدة البيانات: |
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