دورية
Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy
| العنوان: | Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy |
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| المؤلفون: | Wang, Xianwen, Zhong, Xiaoyan, Bai, Lixin, Xu, Jun, Gong, Fei, Dong, Ziliang, Yang, Zhijuan, Zeng, Zhijie, Liu, Zhuang, Cheng, Liang |
| المصدر: | Journal of the American Chemical Society; April 2020, Vol. 142 Issue: 14 p6527-6537, 11p |
| مستخلص: | Ultrasound (US)-triggered sonodynamic therapy (SDT) that enables noninvasive treatment of large internal tumors has attracted widespread interest. For improvement in the therapeutic responses to SDT, more effective and stable sonosensitizers are still required. Herein, ultrafine titanium monoxide nanorods (TiO1+xNRs) with greatly improved sono-sensitization and Fenton-like catalytic activity were fabricated and used for enhanced SDT. TiO1+xNRs with an ultrafine rodlike structure were successfully prepared and then modified with polyethylene glycol (PEG). Compared to the conventional sonosensitizer, TiO2nanoparticles, the PEG–TiO1+xNRs resulted in much more efficient US-induced generation of reactive oxygen species (ROS) because of the oxygen-deficient structure of TiO1+xNR, which predominantly serves as the charge trap to limit the recombination of US-triggered electron–hole pairs. Interestingly, PEG–TiO1+xNRs also exhibit horseradish-peroxidase-like nanozyme activity and can produce hydroxyl radicals (•OH) from endogenous H2O2in the tumor to enable chemodynamic therapy (CDT). Because of their efficient passive retention in tumors post intravenous injection, PEG–TiO1+xNRs can be used as a sonosensitizer and CDT agent for highly effective tumor ablation under US treatment. In addition, no significant long-term toxicity of PEG–TiO1+xNRs was found for the treated mice. This work highlights a new type of titanium-based nanostructure with great performance for tumor SDT. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 00027863 15205126 |
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| DOI: | 10.1021/jacs.9b10228 |