دورية
Efficient production of male Wolbachia-infected Aedes aegyptimosquitoes enables large-scale suppression of wild populations
العنوان: | Efficient production of male Wolbachia-infected Aedes aegyptimosquitoes enables large-scale suppression of wild populations |
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المؤلفون: | Crawford, Jacob E., Clarke, David W., Criswell, Victor, Desnoyer, Mark, Cornel, Devon, Deegan, Brittany, Gong, Kyle, Hopkins, Kaycie C., Howell, Paul, Hyde, Justin S., Livni, Josh, Behling, Charlie, Benza, Renzo, Chen, Willa, Dobson, Karen L., Eldershaw, Craig, Greeley, Daniel, Han, Yi, Hughes, Bridgette, Kakani, Evdoxia, Karbowski, Joe, Kitchell, Angus, Lee, Erika, Lin, Teresa, Liu, Jianyi, Lozano, Martin, MacDonald, Warren, Mains, James W., Metlitz, Matty, Mitchell, Sara N., Moore, David, Ohm, Johanna R., Parkes, Kathleen, Porshnikoff, Alexandra, Robuck, Chris, Sheridan, Martin, Sobecki, Robert, Smith, Peter, Stevenson, Jessica, Sullivan, Jordan, Wasson, Brian, Weakley, Allison M., Wilhelm, Mark, Won, Joshua, Yasunaga, Ari, Chan, William C., Holeman, Jodi, Snoad, Nigel, Upson, Linus, Zha, Tiantian, Dobson, Stephen L., Mulligan, F. Steven, Massaro, Peter, White, Bradley J. |
المصدر: | Nature Biotechnology; April 2020, Vol. 38 Issue: 4 p482-492, 11p |
مستخلص: | The range of the mosquito Aedes aegypticontinues to expand, putting more than two billion people at risk of arboviral infection. The sterile insect technique (SIT) has been used to successfully combat agricultural pests at large scale, but not mosquitoes, mainly because of challenges with consistent production and distribution of high-quality male mosquitoes. We describe automated processes to rear and release millions of competitive, sterile male Wolbachia-infected mosquitoes, and use of these males in a large-scale suppression trial in Fresno County, California. In 2018, we released 14.4 million males across three replicate neighborhoods encompassing 293 hectares. At peak mosquito season, the number of female mosquitoes was 95.5% lower (95% CI, 93.6–96.9) in release areas compared to non-release areas, with the most geographically isolated neighborhood reaching a 99% reduction. This work demonstrates the high efficacy of mosquito SIT in an area ninefold larger than in previous similar trials, supporting the potential of this approach in public health and nuisance-mosquito eradication programs. |
قاعدة البيانات: | Supplemental Index |
تدمد: | 10870156 15461696 |
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DOI: | 10.1038/s41587-020-0471-x |