دورية
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle
| العنوان: | Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle |
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| المؤلفون: | Goodman, MG, Wormsley, SB, Spinosa, JC, Piro, LD |
| المصدر: | Blood; November 1994, Vol. 84 Issue: 10 p3457-3464, 8p |
| مستخلص: | Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated and undergo DNA synthesis and mitosis accompanied by a marked increase in expression of an array of cell surface activation antigens. The resultant activated B-CLL cells exhibit greatly enhanced sensitivity to cycle-active cytotoxic drugs. This approach may be of potential value in the therapy of CLL. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V84.10.3457.3457 |