دورية
Wasp venom peptide, synoeca‐MP, from Synoeca surinamashows antimicrobial activity against human and animal pathogenic microorganisms
| العنوان: | Wasp venom peptide, synoeca‐MP, from Synoeca surinamashows antimicrobial activity against human and animal pathogenic microorganisms |
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| المؤلفون: | Freire, Daniel O., da Cunha, Nicolau B., Leite, Michel L., Kostopoulos, Alessandra G. C., da Silva, Sheila N. B., Souza, Adolfo C. B., Nolasco, Diego O., Franco, Octávio L., Mortari, Márcia R., Dias, Simoni C. |
| المصدر: | Peptide Science; May 2020, Vol. 112 Issue: 3 |
| مستخلص: | The rising number of multidrug‐resistant microorganisms has triggered interest in the prospection of biocompounds with antimicrobial activities. Synoeca‐MP consists of an antimicrobial peptide (AMP) classified as a mastoparan, which was isolated from the venom of Synoeca surinama, a social wasp. Synoeca‐MP presented a potent antimicrobial activity, with values of MIC50and MIC90against methicillin‐resistant Staphylococcus aureus—MRSA (1.9 and 2.2 μM), Escherichia coliESBL (2.0 and 2,1 μM), vancomycin‐resistant Enterococcus faecalis(8.3 and 17.1 μM), Pseudomonas aeruginosametallo‐ß‐lactamase (5.2 and 5.9 μM), and Klebsiella pneumoniaeKPC (3.5 and 4.7 μM). Synoeca‐MP was also tested against six Candidaspecies, with MICs varying from 10 to 40 μM. Moreover, the structural prediction for Synoeca‐MP demonstrated a cationic α‐helix capable of interacting with in silico membranes and low hemolytic activity. Due to its antimicrobial activity, synoeca‐MP shows potential as an adjuvant to antibiotics and antifungals commonly used in antibiotic therapies. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 13447661 24758817 |
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| DOI: | 10.1002/pep2.24141 |