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Association of dyslipidaemia with Alzheimer’s disease in a cohort of postmenopausal women

التفاصيل البيبلوغرافية
العنوان: Association of dyslipidaemia with Alzheimer’s disease in a cohort of postmenopausal women
المؤلفون: Li, Ning, Xu, Xiaoying, Mao, Shuai, Jiang, Ye, Hu, Yadong, Xing, Ruowei, Chen, Yajing, Ye, Junxing, Ling, Li, Zeng, Xianshang, Han, Guowei
المصدر: Journal of International Medical Research; 20210101, Issue: Preprints
مستخلص: Objective To evaluate the association between dyslipidaemia and Alzheimer’s disease (AD) in a cohort of postmenopausal women.Methods This retrospective study analysed data from postmenopausal women with early AD (group AD) and a cohort of healthy age- and sex-matched control subjects (group NC) that were considered to be within standard limits according to a neuropsychological assessment between March 2010 and March 2019. The primary endpoints were body mass index and lipid-related laboratory parameters, including leptin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, adiponectin, triglycerides, apolipoprotein A1, apolipoprotein B and apolipoprotein E4, which were evaluated using multivariate binary logistic analysis.Results The study enrolled 200 postmenopausal women with early AD (mean ± SD age 69.34 ± 6.25 years) and 180 control subjects (mean ± SD age 67.48 ± 7.42 years). Lower HDL-C and higher LDL-C were risk factors for AD. A multivariate binary logistic regression model demonstrated that lower HDL-C and higher LDL-C were the only variables associated with the development of AD (odds ratio [OR] 21.14, 95% confidence interval [CI] 2.47, 4.13; OR 36.35, 95% CI 1.24, 3.38; respectively).Conclusion Both low HDL-C and high LDL-C were associated with the occurrence of AD in a cohort of postmenopausal women.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:03000605
14732300
DOI:10.1177/0300060520926020