دورية
Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy
| العنوان: | Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy |
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| المؤلفون: | Bai, Shang, Yang, Nailin, Wang, Xianwen, Gong, Fei, Dong, Ziliang, Gong, Yuehan, Liu, Zhuang, Cheng, Liang |
| المصدر: | ACS Nano; November 2020, Vol. 14 Issue: 11 p15119-15130, 12p |
| مستخلص: | Sonodynamic therapy (SDT), which can generate reactive oxygen species (ROS) based on sonosensitizers under ultrasound (US) to kill tumor cells, has emerged as a noninvasive therapeutic modality with high tissue-penetration depth. Herein, ultrasmall iron-doped titanium oxide nanodots (Fe-TiO2NDs) are synthesized viaa thermal decomposition strategy as a type of sonosensitizers to enhance SDT. Interestingly, the Fe doping in this system appears to be crucial in not only enhancing the US-triggered ROS generation of those NDs but also offering NDs the Fenton-catalytic function to generate ROS from tumor endogenous H2O2for chemodynamic therapy (CDT). After polyethylene glycol (PEG) modification, Fe-TiO2-PEG NDs demonstrate good physiological stability and biocompatibility. With efficient tumor retention after intravenous injection as revealed by in vivomagnetic resonance (MR) and fluorescent imaging, our Fe-TiO2NDs demonstrate much better in vivotherapeutic performance than commercial TiO2nanoparticles owing to the combination of CDT and SDT. Moreover, most of those ultrasmall Fe-TiO2NDs can be effectively excreted within one month, rendering no obvious long-term toxicity to the treated mice. Our work thus presents a type of multifunctional sonosensitizer for highly efficient cancer treatment viasimply doping TiO2nanostructures with metal ions. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 19360851 1936086X |
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| DOI: | 10.1021/acsnano.0c05235 |