التفاصيل البيبلوغرافية
| العنوان: |
Transient Hepatotoxicity Induced by Vinblastine in a Young Girl with Chiasmatic Low Grade Glioma |
| المؤلفون: |
Franke, Niels E., Blok, Geert Jan, Voll, Marsha L., Schouten-van Meeteren, Antoinette Y.N. |
| المصدر: |
Current Drug Safety; 2020, Vol. 15 Issue: 3 p231-235, 5p |
| مستخلص: |
Background: Vinblastine (VBL) is a cytostatic drug frequently applied in children with lymphoma and progressive low-grade glioma (LGG), with hematotoxicity as the main side effect. Case Report: Here, the case of a 7-month-old girl with tumor progression of an LGG during standard chemotherapy with carboplatin and vincristine, is presented. Switching to VBL led to a 20-30- fold increase of transaminases (grade IV CTCAE 5.0), spontaneously resolving after the end of treatment. The toxicity is possibly age-related since it did not re-occur at the restart of VBL at 4 years old. This finding might have consequences for toxicity screening in future protocols, especially when including infants. |
| قاعدة البيانات: |
Supplemental Index |
