دورية
Steroid Structure and Androgenic Activity
| العنوان: | Steroid Structure and Androgenic Activity |
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| المؤلفون: | Liao, Shutsung, Liang, Tehming, Fang, Senmaw, Castañeda, Evangelina, Shao, Tsang-Cheng |
| المصدر: | Journal of Biological Chemistry; September 1973, Vol. 248 Issue: 17 p6154-6162, 9p |
| مستخلص: | In rat ventral prostate the action of many natural androgens, including testosterone, appears to depend on their conversion to 5α-dihydrotestosterone that binds firmly to an androgen receptor (β protein) and is subsequently retained by cell nuclei. We have found, however, that many potent synthetic androgens can bind directly to β protein and to prostate cell nuclei without a metabolic conversion. For these studies, simple methods were devised to compare the receptor binding affinities of various androgenic steroids. These methods are especially useful if test compounds are available only in minute quantities (<1 µg). In general, the correlation between the relative competition indices of various synthetic androgens determined by these procedures and the relative androgenicities of these androgens was very good. This supports the concept that the β protein and nuclear binding of androgens play important roles in androgen actions in ventral prostates. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00219258 1083351X |
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| DOI: | 10.1016/S0021-9258(19)43521-7 |