دورية
ASCL1 represses a SOX9+neural crest stem-like state in small cell lung cancer
| العنوان: | ASCL1 represses a SOX9+neural crest stem-like state in small cell lung cancer |
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| المؤلفون: | Olsen, Rachelle R., Ireland, Abbie S., Kastner, David W., Groves, Sarah M., Spainhower, Kyle B., Pozo, Karine, Kelenis, Demetra P., Whitney, Christopher P., Guthrie, Matthew R., Wait, Sarah J., Soltero, Danny, Witt, Benjamin L., Quaranta, Vito, Johnson, Jane E., Oliver, Trudy G. |
| المصدر: | Genes & Development; 2021, Vol. 35 p847-869, 23p |
| مستخلص: | In this study, Olsen et al. show that alterations in Rb1/Trp53/Myc in the mouse lung induce an ASCL1+state of small cell lung cancer (SCLC) in multiple cells of origin. Their findings show that in a MYC-driven SCLC model, ASCL1 promotes neuroendocrine fate and represses the emergence of a SOX9+nonendodermal stem-like fate that resembles neural crest. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 08909369 15495477 |
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| DOI: | 10.1101/gad.348295.121 |