دورية
Pharmacokinetics of enoxacin and its oxometabolite following intravenous administration to patients with different degrees of renal impairment
العنوان: | Pharmacokinetics of enoxacin and its oxometabolite following intravenous administration to patients with different degrees of renal impairment |
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المؤلفون: | Van der Auwera, P, Stolear, J C, George, B, Dudley, M N |
المصدر: | Antimicrobial Agents and Chemotherapy; August 1990, Vol. 34 Issue: 8 p1491-1497, 7p |
مستخلص: | Enoxacin is a fluorinated quinolone with potential clinical use in the treatment of serious infections. Twenty-three patients (age, 19 to 87 years) with different degrees of renal function, including a group undergoing chronic hemodialysis, received enoxacin (400 mg) by intravenous infusion (1 h). Blood samples were collected before infusion; at the end of infusion; and at 5, 10, 20, 30, 45, 60, 90, and 120 min and 3, 4, 6, 12, 18, 24, 48, and 72 h after infusion. Enoxacin and oxoenoxacin concentrations were measured by high-pressure liquid chromatography. Pharmacokinetic parameters (mean +/- standard deviation) were calculated by using a noncompartmental PK model according to creatinine clearances (in milliliters per minute). Total clearance of enoxacin decreased from 4.95 +/- 1.16 ml/min per kg in the group with normal creatinine clearance to 0.76 +/- 0.21 ml/min per kg in the patients with severe renal failure (creatinine clearance, less than 15 ml/min), whereas the elimination half-life increased from 4.5 +/- 1.0 to 20 +/- 5 h, respectively. The elimination of oxoenoxacin (the main metabolite of enoxacin) in urine was markedly decreased when creatinine clearance was less than 15 ml/min. Hemodialysis removed an insignificant amount of enoxacin and oxoenoxacin. These data indicate that as creatinine clearance falls below 30 ml/min, the daily enoxacin dose should be reduced by half. During prolonged administration of enoxacin to patients with creatinine clearances of less than 30 ml/min, the accumulation of oxoenoxacin might lead to unexpected side effects. |
قاعدة البيانات: | Supplemental Index |
تدمد: | 00664804 10986596 |
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DOI: | 10.1128/AAC.34.8.1491 |