دورية
Substrate Envelope and Drug Resistance: Crystal Structure of RO1 in Complex with Wild-Type Human Immunodeficiency Virus Type 1 Protease
| العنوان: | Substrate Envelope and Drug Resistance: Crystal Structure of RO1 in Complex with Wild-Type Human Immunodeficiency Virus Type 1 Protease |
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| المؤلفون: | Prabu-Jeyabalan, Moses, King, Nancy M., Nalivaika, Ellen A., Heilek-Snyder, Gabrielle, Cammack, Nick, Schiffer, Celia A. |
| المصدر: | Antimicrobial Agents and Chemotherapy; April 2006, Vol. 50 Issue: 4 p1518-1521, 4p |
| مستخلص: | ABSTRACTIn our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved “envelope” that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00664804 10986596 |
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| DOI: | 10.1128/AAC.50.4.1518-1521.2006 |