The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparumparasite resistance

التفاصيل البيبلوغرافية
العنوان: The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparumparasite resistance
المؤلفون: Murithi, James M., Pascal, Cécile, Bath, Jade, Boulenc, Xavier, Gnädig, Nina F., Pasaje, Charisse Flerida A., Rubiano, Kelly, Yeo, Tomas, Mok, Sachel, Klieber, Sylvie, Desert, Paul, Jiménez-Díaz, María Belén, Marfurt, Jutta, Rouillier, Mélanie, Cherkaoui-Rbati, Mohammed H., Gobeau, Nathalie, Wittlin, Sergio, Uhlemann, Anne-Catrin, Price, Ric N., Wirjanata, Grennady, Noviyanti, Rintis, Tumwebaze, Patrick, Cooper, Roland A., Rosenthal, Philip J., Sanz, Laura M., Gamo, Francisco Javier, Joseph, Jayan, Singh, Shivendra, Bashyam, Sridevi, Augereau, Jean Michel, Giraud, Elie, Bozec, Tanguy, Vermat, Thierry, Tuffal, Gilles, Guillon, Jean-Michel, Menegotto, Jérôme, Sallé, Laurent, Louit, Guillaume, Cabanis, Marie-José, Nicolas, Marie Françoise, Doubovetzky, Michel, Merino, Rita, Bessila, Nadir, Angulo-Barturen, Iñigo, Baud, Delphine, Bebrevska, Lidiya, Escudié, Fanny, Niles, Jacquin C., Blasco, Benjamin, Campbell, Simon, Courtemanche, Gilles, Fraisse, Laurent, Pellet, Alain, Fidock, David A., Leroy, Didier
المصدر: Science Translational Medicine; July 2021, Vol. 13 Issue: 603 peabg6013
مستخلص: We report an acylguanidine preclinical candidate with pharmacological features compatible with single low-dose malaria cure.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:19466234
19466242
DOI:10.1126/scitranslmed.abg6013