دورية
PHYTOHEMAGGLUTININ MITOGENIC PROTEINS
| العنوان: | PHYTOHEMAGGLUTININ MITOGENIC PROTEINS |
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| المؤلفون: | Miller, J. Bruce, Noyes, Claudia, Heinrikson, Robert, Kingdon, Henry S., Yachnin, Stanley |
| المصدر: | The Journal of Experimental Medicine; October 1973, Vol. 138 Issue: 4 p939-951, 13p |
| مستخلص: | The phytohemagglutinin (PHAP) glycoproteins derived from Phaseolus vulgaris consist of five isomitogens that are tetrameric structures made up of two different glycoprotein subunits. Although identical in size (mol wt = 34,000), the subunits differ in their isoelectric points and amino acid sequences for six of the first seven amino-terminal residues, but are identical in primary structure from the 8th through the 24th amino acid residue. The isomitogen containing four L subunits (L-PHAP) is a potent leukoagglutinin and mitogen that lacks hemagglutinating properties. The isomitogen made up of four R subunits (4R H-PHAP) is a potent hemagglutinin. The hybrid isomitogens consisting of varying proportions of the two subunits (3L-1R, 2L-2R, 1L-3R) are capable of causing mixed erythrocyte-lymphocyte agglutination. These studies provide a structural basis for explaining the differences in biological activities of the various PHAP isomitogens. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00221007 15409538 |
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| DOI: | 10.1084/jem.138.4.939 |