دورية
Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element
| العنوان: | Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element |
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| المؤلفون: | Bogerd, H P, Tiley, L S, Cullen, B R |
| المصدر: | The Journal of Virology; December 1992, Vol. 66 Issue: 12 p7572-7575, 4p |
| مستخلص: | Expression of the structural proteins of human T-cell leukemia virus type I is dependent upon the interaction of the viral Rex trans activator with its highly structured cis-acting RNA target sequence, the 254-nucleotide Rex-response element. Nucleotides critical for Rex binding in vitro have been mapped by modification interference analysis to a discrete 12-nucleotide RNA sequence that is predicted to form a stem-bulge-stem structure. This minimal RNA binding site was sufficient to mediate specific Rex binding in vitro when analyzed in the context of a short RNA probe. The critical importance of this short RNA sequence in mediating Rex function in vivo is supported by its complete conservation among all primate T-cell leukemia virus isolates. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 0022538X 10985514 |
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| DOI: | 10.1128/jvi.66.12.7572-7575.1992 |