دورية
Emergence of Virulent Methicillin-Resistant Staphylococcus aureusStrains Carrying Panton-Valentine Leucocidin Genes in The Netherlands
| العنوان: | Emergence of Virulent Methicillin-Resistant Staphylococcus aureusStrains Carrying Panton-Valentine Leucocidin Genes in The Netherlands |
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| المؤلفون: | Wannet, W. J. B., Spalburg, E., Heck, M. E. O. C., Pluister, G. N., Tiemersma, E., Willems, R. J. L., Huijsdens, X. W., de Neeling, A. J., Etienne, J. |
| المصدر: | Journal of Clinical Microbiology; July 2005, Vol. 43 Issue: 7 p3341-3345, 5p |
| مستخلص: | ABSTRACTMethicillin-resistant Staphylococcus aureus(MRSA) strains carrying the Panton-Valentine leucocidin (PVL) genes have been reported worldwide and are a serious threat to public health. The PVL genes encode a highly potent toxin which is involved in severe skin infections and necrotizing pneumonia, even in previously healthy individuals. We assessed the prevalence of PVL-positive MRSA in The Netherlands for two periods of time: (i) 1987 through 1995 and (ii) 2000 and 2002, and determined their characteristics by using multilocus sequence typing and staphylococcal chromosome cassette (SCCmec) typing. It was found that up to 15% of all MRSA isolates detected in The Netherlands harbored the PVL genes. Most PVL-positive MRSA isolates were obtained from severe soft tissue infections in relatively young individuals. The first PVL-positive MRSA described in The Netherlands, isolated in 1988, was a single-locus variant of the “Berlin” epidemic MRSA clone. The 20 PVL-positive MRSA isolates studied in 2000 and 2002 consisted of five different sequence types (STs) that belonged to four clonal complexes. One of the STs, ST80, is considered to be a widespread European clone and was the most predominant ST (60%) in this study, while ST37 had never been found to be associated with PVL-positive MRSA. Most isolates harbored SCCmectype IV, a supposed marker for community-acquired MRSA. The number and type of virulence-associated genes varied among the different STs. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00951137 1098660X |
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| DOI: | 10.1128/JCM.43.7.3341-3345.2005 |