التفاصيل البيبلوغرافية
| العنوان: |
99mTc-Luteolin: Radiolabeling, In SilicoADMET and Biological Evaluation as a Natural Tracer Tumor imaging |
| المؤلفون: |
El-Sharawy, Dina M., Khater, S.I., H.M, Essam, Sherif, Noheir H., Hassan, Hossam M., Elmaidomy, Abeer H. |
| المصدر: |
Journal of Radiation Research and Applied Sciences; December 2021, Vol. 14 Issue: 1 p125-132, 8p |
| مستخلص: |
The focus of the staged work was radiolabelled 5,7,3ʹ, 4ʹ tetra-hydroxy flavone (Luteolin), isolated from Plantago lanceolataL., (F. Plantaginaceae), with 99mtechnetium (99mTc) to produce a natural tracer 99mTc-Luteolin (99mTc-Lut), and to evaluate the biological distribution in silicoand in vivo. Labeling was carried out by reduction reaction using SnCl2as reducing agent giving a maximum radiochemical yield (RCY) up to 97% at 40°C, pH4, for 30 min., with concentration of 99mTc and Luteolin of 150 μL. The tracer (99mTc-Lut) showed 12 h., in vitrostability. In silicoADMET screening of 99mTc-Lut indicated its high bioavailability in all body organs. The bio-distribution profile indicating the highly uptake of the tracer 99mTc-Lut, in tumor mice target/non-target ratio (T/NT) up to two-fold compared to normal mice, whereas the clearance from mice was observed via both renal and feces pathway. 99mTc-Lut, could be valued as a probable natural radiopharmaceutical tracer for tumor appearance. |
| قاعدة البيانات: |
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