دورية
Decrease of Fibronectin Following Repeated Infusion of Highly Substituted Hydroxyethyl Starch
| العنوان: | Decrease of Fibronectin Following Repeated Infusion of Highly Substituted Hydroxyethyl Starch |
|---|---|
| المؤلفون: | Treib, J., Haass, A., Pindur, G., Grauer, M.T., Wenzel, E., Schimrigk, K. |
| المصدر: | Infusion Therapy and Transfusion Medicine (Infusionstherapie und Transfusionsmedizin); October 2010, Vol. 23 Issue: 2 p71-75, 5p |
| مستخلص: | Objective:Fibronectin (Fn) plays an important part in unspecific defense mechanisms because of its ability to mediate the binding of foreign-body particles, bacteria, collagen, and other macromolecules to phagocytising cells of the reticulo-endothe-lial system (RES). The aim of the present study was to examine the effect of a 10-day hemodilution therapy on Fn concentration in humans. Design:The patients were randomized and treated with either 10% hydroxyethyl starch (HES) 200/0,62 or 6% HES 200/0,62. Setting:Neurology department of an university clinic. Patients:We examined 12 patients with cerebrovascular perfusion disturbances. Interventions:The Fn concentration was determined using simple radial immunodif-fusion. Results:The Fn concentration dropped significantly in all 12 patients (p < 0.01) in a dose-dependent manner beyond the dilution effect. 10% HES 200/0,62 caused a Fn decrease from 26.6 ± 9.2 to 10.0 ± 2.2 mg/dl (-62.2%), 6% HES reduced Fn from 25.5 ± 9.9 to 15.0 ± 3.2 mg/dl (-41.1%). In one patient there was a continuous decrease of Fn from 41.0 down to only 6.4 mg/dl. Conclusion:According to the results of animal experiments, the decrease of Fn seems to indicate depression of the RES. Besides its defense function, Fn probably plays a role in embryogenesis, wound healing, and blood clotting. Therefore, we assume that the drug-induced reduction of Fn possibly has clinical relevance. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 10198466 14230089 |
|---|---|
| DOI: | 10.1159/000223261 |