دورية
Protective efficacy of Coriandrum sativumseeds against arsenic induced toxicity in Swiss albino mice
| العنوان: | Protective efficacy of Coriandrum sativumseeds against arsenic induced toxicity in Swiss albino mice |
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| المؤلفون: | Kumar, Arun, Kumar, Vikas, Akhouri, Vivek, Kumar, Ranjit, Ali, Mohammad, Rashmi, Tuhin, Chand, Gyanendra Bahadur, Singh, Sushil Kumar, Ghosh, Ashok Kumar |
| المصدر: | Toxicological Research; October 2022, Vol. 38 Issue: 4 p437-447, 11p |
| مستخلص: | Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic exposure through drinking water to humans leads to major public health related issues. There have been very meagre studies which reported that, the plant constituents proved to exhibit protective effect from arsenicosis. Therefore, the present study aims to evaluate the protective efficacy of Coriandrum sativumseeds extract against sodium arsenite induced toxicity in Swiss albino mice. In the present study twenty-four male healthy Swiss albino mice (30 ± 5 g) were divided into four groups (n= 6), where the control group received normal diet and water; group II and group III treated with sodium arsenite (2 mg per kg body weight per day) for 2 and 4 weeks respectively. The group IV mice were administered with C.sativumseeds extract at the dose of 150 mg per kg body weight per day for 4 weeks upon sodium arsenite pretreated (2 mg/kg body weight for 4 weeks per day) mice. After the complete dose duration, all the treatment group animals were sacrificed same day for haematological, biochemical and histopathological study. In the arsenic treated mice, there were significant (p< 0.0001) changes in the serum levels of ALT, AST, ALP, urea, uric acid and creatinine as well as in the haematological parameters. In contrast, after the administration with C.sativumseeds extract upon arsenic pretreated mice, there was significant (p< 0.0001) improvement observed in the hepatic and renal biomarker parameters as well as haematological variables. In the arsenic intoxicated mice, after administration with C.sativumseeds extract there was significant (p< 0.0001) reduction in the arsenic concentration in blood, liver and kidney tissues as well as in the serum LPO levels. Furthermore, the histopathological study showed that, C.sativumseeds extract administrated group of mice significantly restored the liver and kidney at cellular level against arsenic induced toxicity. The entire study concludes that C.sativumseeds extract possesses the ameliorative effect against arsenic induced liver and kidney intoxication. |
| قاعدة البيانات: | Supplemental Index |
Find this article in full text from Springer Verlag. | تدمد: | 19768257 22342753 |
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| DOI: | 10.1007/s43188-022-00123-7 |