دورية
Antifungal Activity of Green and Red Brazilian Propolis Extracts
| العنوان: | Antifungal Activity of Green and Red Brazilian Propolis Extracts |
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| المؤلفون: | Messias, Anny Caroline, Lopes, Gabriela Fonseca, de Moura Almeida, Bruno, Almeida, Jane José, Abreu, José Alexandre, Binda, Nancy S., Caligiorne, Rachel Basques, Vieira-Filho, Sidney Augusto, Johann, Susana, de Figueiredo, Sônia Maria, de Freitas, Márcia Christina Dornelas, de Sá, Nívea Pereira, Carvalho, Blenda Fernandes |
| المصدر: | The Natural Products Journal; 2022, Vol. 12 Issue: 2 |
| مستخلص: | Background: Diseases associated to Candida spp. are recurrent and can be difficult totreat, mainly due to the new strains resistant to the limited number of available antifungals. Objectives: The objective of this study is to evaluate the in vitro and in vivo activity of Braziliangreen propolis (GrProp) and red propolis (RdProp) ethanolic extracts against standard strains ofCandida albicans, C. tropicalis, C. krusei, C. glabrata, C. parapsilosis and 10 clinical isolates ofC. albicans. Methods: Antifungal activity in vitro was tested using the M-27-A3/CLSI protocol. The in vivo antifungalactivity was evaluated using Tenebrio molitor model and, the effect of extracts on adhesionof C. albicans in human buccal epithelial cells (BECs) was also studied. Results: GrProp and RdProp exhibited antifungal activity against at least one of the Candidastrains tested. The adhesion inhibition of C. albicans in BECs was 45% (GrProp28), 60% (Gr-Prop50) and 82% (RdProp), in comparison to amphotericin B (82%). All propolis extracts showedsynergistic activity with fluconazole and amphotericin B. GrProp50 (10 mg/kg) showed better protectionof T. molitor, blocking the progression of C. albicans infection, increasing survival and delayedthe larvae death. Conclusion: Brazilian GrProp and RdProp extracts inhibit the in vitro C. albicans growth and protectT. molitor against infection by this yeast. The physiochemical parameters found for the analyzedsamples were in accordance to the standards established by the Brazilian Legislation forpropolis and derivatives. GrProp and RdProp have potential to be used against Candida spp. infections,mainly in association with fluconazole or amphotericin B. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 22103155 22103163 |
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| DOI: | 10.2174/2210315511666210302161514 |