دورية
Cell-cycle-specific interaction of nuclear DNA-binding proteins with a CCAAT sequence from the human thymidine kinase gene.
| العنوان: | Cell-cycle-specific interaction of nuclear DNA-binding proteins with a CCAAT sequence from the human thymidine kinase gene. |
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| المؤلفون: | Knight, G B, Gudas, J M, Pardee, A B |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America; December 1987, Vol. 84 Issue: 23 p8350-8354, 5p |
| مستخلص: | Induction of thymidine kinase parallels the onset of DNA synthesis. To investigate the transcriptional regulation of the thymidine kinase gene, we have examined whether specific nuclear factors interact in a cell-cycle-dependent manner with sequences upstream of this gene. Two inverted CCAAT boxes near the transcriptional initiation sites were observed to form complexes with nuclear DNA-binding proteins. The nature of the complexes changes dramatically as the cells approach DNA synthesis and correlates well with the previously reported transcriptional increase of the thymidine kinase gene. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00278424 10916490 |
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| DOI: | 10.1073/pnas.84.23.8350 |