دورية
Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.
| العنوان: | Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes. |
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| المؤلفون: | Celis, E, Tsai, V, Crimi, C, DeMars, R, Wentworth, P A, Chesnut, R W, Grey, H M, Sette, A, Serra, H M |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America; March 1994, Vol. 91 Issue: 6 p2105-2109, 5p |
| مستخلص: | Cytotoxic T lymphocytes (CTLs) recognize peptide antigens associated with cell surface major histocompatibility complex (MHC) molecules. The identification of tumor cell-derived peptides capable of eliciting anti-tumor CTL responses would enable the design of antigen-specific immunotherapies. Our strategy to identify such potentially therapeutic peptides relies on selecting high-affinity MHC binders from known tumor-associated antigens. These peptides are subsequently tested for their ability to induce CTLs capable of killing tumor cells. With this strategy, we have identified a nine-residue epitope, derived from the product of the tumor-associated gene MAGE-3, which has the capacity to induce in vitro CTLs that kill melanoma and other tumor cell lines. These results show the primary in vitro induction of tumor-specific human CTLs and illustrate the feasibility of ex vivo antigen-specific approaches to the immunological therapy of cancer. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00278424 10916490 |
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| DOI: | 10.1073/pnas.91.6.2105 |