دورية
In vivomeasurement of human brain material properties under quasi-static loading
| العنوان: | In vivomeasurement of human brain material properties under quasi-static loading |
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| المؤلفون: | Bennion, Nicholas J., Zappalá, Stefano, Potts, Matthew, Woolley, Max, Marshall, David, Evans, Sam L. |
| المصدر: | Journal of The Royal Society Interface; December 2022, Vol. 19 Issue: 197 |
| مستخلص: | Computational modelling of the brain requires accurate representation of the tissues concerned. Mechanical testing has numerous challenges, in particular for low strain rates, like neurosurgery, where redistribution of fluid is biomechanically important. A finite-element (FE) model was generated in FEBio, incorporating a spring element/fluid–structure interaction representation of the pia–arachnoid complex (PAC). The model was loaded to represent gravity in prone and supine positions. Material parameter identification and sensitivity analysis were performed using statistical software, comparing the FE results to human in vivomeasurements. Results for the brain Ogden parameters µ, αand kyielded values of 670 Pa, −19 and 148 kPa, supporting values reported in the literature. Values of the order of 1.2 MPa and 7.7 kPa were obtained for stiffness of the pia mater and out-of-plane tensile stiffness of the PAC, respectively. Positional brain shift was found to be non-rigid and largely driven by redistribution of fluid within the tissue. To the best of our knowledge, this is the first study using in vivohuman data and gravitational loading in order to estimate the material properties of intracranial tissues. This model could now be applied to reduce the impact of positional brain shift in stereotactic neurosurgery. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 17425689 17425662 |
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| DOI: | 10.1098/rsif.2022.0557 |