دورية
Calcium Hydride‐Based Dressing to Promote Wound Healing
| العنوان: | Calcium Hydride‐Based Dressing to Promote Wound Healing |
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| المؤلفون: | Gong, Fei, Yang, Nailin, Xu, Jiachen, Yang, Xiaoyuan, Wei, Kailu, Hou, Linqian, Liu, Bo, Zhao, He, Liu, Zhuang, Cheng, Liang |
| المصدر: | Advanced Healthcare Materials; January 2023, Vol. 12 Issue: 2 |
| مستخلص: | Wound microenvironment with excess reactive oxygen species (ROS) can significantly inhibit wound healing. Encouraged by hydrogen molecules (H2) with effective ROS scavenging and calcium hydride (CaH2) with sufficient H2supply, the authors for the first time employed CaH2as a therapeutic H2donor and starch as a diluent to construct CaH2pulvis dressing for wound healing treatment. It has been found that CaH2by generating H2exhibited excellent ROS scavenging performance, favorable for preserving the oxidative‐stress‐induced cell death. After being applied onto the skin wound, the CaH2pulvis dressing with the unique ROS‐scavenging ability can accelerate skin wound healing in healthy/diabetic mice (small animal models) and Bama mini‐pigs (large animal model). Such CaH2dressing can release H2to relieve the inflammation levels, decrease the secretion of pro‐inflammatory cytokines, increase the infiltration of inflammation‐suppressive immune cells, and promote the regeneration of new blood vessels and collagens, thereby accelerating wound healing. This work highlighted that the integration of anti‐oxidation and anti‐inflammation functions based on CaH2dressing endowed it with a promising possibility for the treatment of inflammatory diseases. Encouraged by hydrogen molecules (H2) with effective ROS scavenging and calcium hydride (CaH2) with enough H2supply, our study employed CaH2as a therapeutic H2donor and starch as a diluent to construct CaH2pulvis dressing for wound healing treatment in healthy/diabetic mice (small animal models) and Bama mini‐pigs (large animal model). |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 21922640 21922659 |
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| DOI: | 10.1002/adhm.202201771 |