Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model

التفاصيل البيبلوغرافية
العنوان: Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model
المؤلفون: Villani, V., Yamada, K., Scalea, J.R., Gillon, B.C., Arn, J.S., Sekijima, M., Tasaki, M., Cormack, T.A., Moran, S.G., Torabi, R., Shimizu, A., Sachs, D.H.
المصدر: American journal of transplantation; January 2016, Vol. 16 Issue: 1 p317-324, 8p
مستخلص: Our recent studies in an inbred swine model demonstrated that both peripheral and intra-graft regulatory cells were required for the adoptive transfer of tolerance to a second, naïve donor-matched kidney. Here, we have asked whether both peripheral and intra-graft regulatory elements are required for adoptive transfer of tolerance when only a long-term tolerant (LTT) kidney is transplanted. Nine highly-inbred swine underwent a tolerance-inducing regimen to prepare LTT kidney grafts which were then transplanted to histocompatible recipients, with or without the peripheral cell populations required for adoptive transfer of tolerance to a naïve kidney. In contrast to our previous studies, tolerance of the LTT kidney transplants alone was achieved without transfer of additional peripheral cells and without strategies to increase the number/potency of regulatory T cells in the donor. This tolerance was systemic, since most subsequent, donor-matched challenge kidney grafts were accepted. These results confirm the presence of a potent tolerance-inducing and/or tolerance-maintaining cell population within LTT renal allografts. They suggest further that additional peripheral tolerance mechanisms, required for adoptive transfer of tolerance to a naïve donor-matched kidney, depend on peripheral cells that, if not transferred with the LTT kidney, require time to develop in the adoptive host.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:16006135
16006143
DOI:10.1111/ajt.13424