دورية
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL
| العنوان: | Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL |
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| المؤلفون: | Largeot, Anne, Klapp, Vanessa, Viry, Elodie, Gonder, Susanne, Fernandez Botana, Iria, Blomme, Arnaud, Benzarti, Mohaned, Pierson, Sandrine, Duculty, Chloé, Marttila, Petra, Wierz, Marina, Gargiulo, Ernesto, Pagano, Giulia, An, Ning, El Hachem, Najla, Perez Hernandez, Daniel, Chakraborty, Supriya, Ysebaert, Loic, François, Jean-Hugues, Cortez, Susan, Berchem, Guy, Efremov, Dimitar G., Dittmar, Gunnar, Szpakowska, Martyna, Chevigne, Andy, Nazarov, Petr V., Helleday, Thomas, Close, Pierre, Meiser, Johannes, Stamatopoulos, Basile, Désaubry, Laurent, Paggetti, Jérôme, Moussay, Etienne |
| المصدر: | Blood; 20230101, Issue: Preprints |
| مستخلص: | •Inhibition of translation initiation prevents CLL growth in vitro and in vivo, through targeting the MYC oncogene.•PHBs directly interact with the translation initiation machinery, filling a gap in the understanding of the crucial roles of these proteins. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.2022017839 |