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A nosocomial Pseudomonas aeruginosaST3495 isolated from a wild Burmese python (Python bivittatus) with suppurative pneumonia and bacteremia in Hainan, China

التفاصيل البيبلوغرافية
العنوان: A nosocomial Pseudomonas aeruginosaST3495 isolated from a wild Burmese python (Python bivittatus) with suppurative pneumonia and bacteremia in Hainan, China
المؤلفون: Li, Roushan, Ling, Bo, Zeng, Jifeng, Wang, Xin, Yang, Nuo, Fan, Lixia, Guo, Guiying, Li, Xuesong, Yan, Fei, Zheng, Jiping
المصدر: Brazilian Journal of Microbiology; September 2023, Vol. 54 Issue: 3 p2403-2412, 10p
مستخلص: Pseudomonas aeruginosais a common infectious agent associated with respiratory diseases in boas and pythons, however, the histopathology, resistance and virulence are yet described for this species. In this study, we investigated a dying Burmese python rescued from tropical rainforest in Hainan. Clinical signs were open-mouthed breathing, abnormal shedding and anorexia. Abundant yellow mucopurulent secretions were observed in highly ectatic segmental bronchi by postmortem. Histopathological lesions included systemic pneumonia, enteritis, nephritis and carditis. P. aeruginosawas the only species isolated from heart blood, kidney, trachea and lung. The phenotype analysis demonstrated that the isolates had strong biofilm, and were sensitive to amikacin, spectinomycin, ciprofloxacin, norfloxacin and polymyxin B, moreover, the LD50of the most virulent isolate was 2.22×105cfu/mL in a zebrafish model. Molecular epidemiological analysis revealed that the isolates belonged to sequence type 3495, the common gene patterns were toxA + exoSYT + phzIM + plcHN in virulence and catB + blaTEM+ ant(3'')-I+ tetA in resistance. This study highlights that P. aeruginosashould be worth more attention in wildlife conservation and raise the public awareness for the cross infection and cross spread between animals and human.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:15178382
16784405
DOI:10.1007/s42770-023-01038-7