التفاصيل البيبلوغرافية
| العنوان: |
Corticosteroid Treatment During Sepsis Alters Hippocampal Function in Male and Female Survivors |
| المؤلفون: |
Hill, Alice, Khalil, Huzefa, Laborc, Klaudia, Kounelis-Wuillaume, Savannah, Gavade, Swapnil, Johnston, Colin, Singer, Benjamin H., Spencer-Segal, Joanna L. |
| المصدر: |
Biological Psychiatry Global Open Science; January 2024, Vol. 4 Issue: 1 p336-345, 10p |
| مستخلص: |
Millions of sepsis survivors annually face neuropsychiatric sequelae of their illness. Corticosteroids are frequently administered for sepsis, and their use improves neuropsychiatric outcomes, but the mechanisms are unknown. In light of prior work that has shown persistent inflammation in sepsis survivors, we hypothesized that short-term corticosteroid treatment during illness would reverse the long-term impact of sepsis on inflammatory gene expression in the hippocampus and rescue associated changes to affective behaviors. |
| قاعدة البيانات: |
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