التفاصيل البيبلوغرافية
| العنوان: |
The LongitudinAlNationwide stuDyon Management And Real‐world outComesof diabetes in India over 3 years (LANDMARCtrial) |
| المؤلفون: |
Das, Ashok K., Kalra, Sanjay, Joshi, Shashank, Mithal, Ambrish, Kumar, K. M. Prasanna, Unnikrishnan, A. G., Thacker, Hemant, Sethi, Bipin, Chowdhury, Subhankar, Sugumaran, Amarnath, Satpathy, Ashwini, Gadekar, Arvind, Menon, Shalini K., Neogi, Renuka, Chodankar, Deepa, Trivedi, Chirag, Wangnoo, S. K., Zargar, A. H., Rais, Nadeem |
| المصدر: |
Endocrinology, Diabetes & Metabolism; September 2023, Vol. 6 Issue: 5 |
| مستخلص: |
LANDMARC (CTRI/2017/05/008452), a prospective, observational real‐world study, evaluated the occurrence of diabetes complications, glycemic control and treatment patterns in people with type 2 diabetes mellitus (T2DM) from pan‐India regions over a period of 3 years. Participants with T2DM (≥25 to ≤60 years old at diagnosis, diabetes duration ≥2 years at the time of enrollment, with/without glycemic control and on ≥2 antidiabetic therapies) were included. The proportion of participants with macrovascular and microvascular complications, glycemic control and time to treatment adaptation over 36 months were assessed. Of the 6234 participants enrolled, 5273 completed 3 years follow‐up. At the end of 3‐years, 205 (3.3%) and 1121 (18.0%) participants reported macrovascular and microvascular complications, respectively. Nonfatal myocardial infarction (40.0%) and neuropathy (82.0%) were the most common complications. At baseline and 3‐years, 25.1% (1119/4466) and 36.6% (1356/3700) of participants had HbA1c <7%, respectively. At 3‐years, population with macrovascular and microvascular complications had higher proportion of participants with uncontrolled glycemia (78.2% [79/101] and 70.3% [463/659], respectively) than those without complications (61.6% [1839/2985]). Over 3‐years, majority (67.7%–73.9%) of the participants were taking only OADs (biguanides [92.2%], sulfonylureas [77.2%] and DPP‐IV inhibitors [62.4%]). Addition of insulin was preferred in participants who were only on OADs at baseline, and insulin use gradually increased from 25.5% to 36.7% at the end of 3 years. These 3‐year trends highlight the burden of uncontrolled glycemia and cumulative diabetes‐related complications, emphasizing the importance of optimizing diabetes management in India. The 3‐year data from the longitudinal LANDMARC study provide valuable insights on diabetes‐related complications, disease progression and treatment strategies among people with diabetes in India. In this pan‐India study, at the end of 3‐years, 205 (3.29%) and 1121 (18.02%) participants reported macrovascular and microvascular complications, respectively, with nonfatal myocardial infarction (40.0%; n= 82) and neuropathy (81.98%; n= 919) being the most common complications. Despite a gradual improvement in glycemic levels, the burden of uncontrolled glycemia (HbA1c > 7%) was considerable (63.4%; n= 2344). The LANDMARC study emphasizes the need for optimizing disease management and timely intensification of therapy among people with diabetes in India. |
| قاعدة البيانات: |
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