دورية
In vivointranasal delivery of coagulation factor IX: a proof-of-concept study
| العنوان: | In vivointranasal delivery of coagulation factor IX: a proof-of-concept study |
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| المؤلفون: | Fieux, Maxime, Rovera, Renaud, Coiffier, Céline, Colomb, Evelyne, Enjolras, Nathalie, Béquignon, Emilie, Monge, Claire, Le Quellec, Sandra |
| المصدر: | Journal of Thrombosis and Haemostasis; November 2023, Vol. 21 Issue: 11 p3117-3123, 7p |
| مستخلص: | Hemophilia B (HB) is a bleeding disorder characterized by coagulation factor (F) IX (FIX) deficiency. The current standard-of-care for severe HB is prophylaxis with long-term repetitive intravenous (i.v.) infusions of recombinant FIX (rFIX) with standard half-life or extended half-life. Unmet needs remain regarding the development of non-invasive administration routes for coagulation factors. The aim of this study was to evaluate the effectiveness of intranasal delivery (IND) of rFIX and rFIX fused to Fc fragment (rFIX-Fc) in mice. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 15387933 15387836 |
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| DOI: | 10.1016/j.jtha.2023.08.019 |