التفاصيل البيبلوغرافية
| العنوان: |
Preparation and characteristics of a thermosensitive in situgel loaded with chitosan nanoparticles for optimal ocular delivery of chloramphenicol |
| المؤلفون: |
Huang, Changying, Peng, Liyang, Xu, Xinqi, Lu, Yunshu, Wang, Xueting, Lan, Zhongming, Chen, Jingdi, Zhou, Yanxia |
| المصدر: |
Journal of Drug Delivery Science and Technology; November 2023, Vol. 89 Issue: 1 |
| مستخلص: |
To enhance the antimicrobial activity of chloramphenicol (CAP) and extend ocular retention, chitosan nanoparticles carrying chloramphenicol (CAP-CNPs) were prepared by ionotropic gelation technique and further incorporated into thermosensitive in situgel (CAP-CNPs-Gel). The formulation of the thermosensitive gel was optimized using a central composite design-response surface methodology (CCD-RSM). The optimized CAP-CNPs-Gel was selected to investigate its drug release kinetics, antimicrobial activity, and ocular irritancy. The average particle size and zeta potential of the optimized CAP-CNPs were 137.5 ± 3.6 nm and 29.9 ± 0.3 mV, respectively. The gel matrix was found to be most effective with a combination of 20.5% (w/v) poloxamer 407 and 5.0% (w/v) poloxamer 188. The CAP-CNPs-Gel formulation demonstrated sustained drug release properties, with drug release lasting up to 18 h. Furthermore, CAP-CNPs-Gel exhibited superior antibacterial activity when compared to both CAP eye drops and CAP gel. Through in vivo studies, CAP-CNPs-Gel was shown to be well tolerated by the eyes and capable of prolonging precorneal retention time for up to 40 min. These promising results suggest that CAP-CNPs-Gel has the potential to serve as a reliable treatment for eye infections. Moreover, the thermosensitive nanoparticulate gelling system utilized in this study provides a valuable carrier for effective CAP delivery. |
| قاعدة البيانات: |
Supplemental Index |
Full Text Finder