دورية
The effect of misonidazole on lymphocytes
| العنوان: | The effect of misonidazole on lymphocytes |
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| المؤلفون: | Clare, M. G., Joslin, C. A. |
| المصدر: | The British Journal of Radiology; November 1978, Vol. 51 Issue: 611 p926-927, 2p |
| مستخلص: | Misonidazole (Ro 07–0582) is a radiosensitizer of hypoxic cells (Denekamp and Harris, 1975). Early studies with radiotherapy patients have been encouraging (Thomlinson et al., 1976). However, peak plasma levels of 100 µg/ml in patients have been associated with neurotoxicity (Dische et al., 1977). Since the drug is cytotoxic (Moore et al., 1976; Josephy et al., 1978) its effect has been tested on human lymphocytes in vitro, to gain insight into other side effects that might occur in clinical practice. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00071285 1748880X |
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| DOI: | 10.1259/0007-1285-51-611-926 |