التفاصيل البيبلوغرافية
| العنوان: |
Optimization of variables and assessment of in-vitroand in-vivoantihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin |
| المؤلفون: |
Gidwani, Bina, Jain, Vishal, Joshi, Veenu, Pandey, Ravindra Kumar, Shukla, Shiv Shankar, Vyas, Amber |
| المصدر: |
Particuology; July 2024, Vol. 90 Issue: 1 p189-198, 10p |
| مستخلص: |
Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitrorelease studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivostudy. |
| قاعدة البيانات: |
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