دورية
Pleosmaranes A–R, Isopimarane and 20-nor Isopimarane Diterpenoids with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Pleosporalessp. HNQQJ-1
| العنوان: | Pleosmaranes A–R, Isopimarane and 20-nor Isopimarane Diterpenoids with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Pleosporalessp. HNQQJ-1 |
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| المؤلفون: | Wang, Guisheng, Yuan, Yilin, Li, Zhaokun, Liu, Xuguang, Chu, Yanhai, She, Zhigang, Kang, Wenyi, Chen, Yan |
| المصدر: | Journal of Natural Products; 20240101, Issue: Preprints |
| مستخلص: | Pleosmaranes A–R (1–18), 18 new isopimarane-type diterpenoids, together with four known analogs (19–22), were isolated from the mangrove endophytic fungus Pleosporalessp. HNQQJ-1. Their structures and absolute configurations were established by analysis of their spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1–9possess an unusual aromatic B ring and a 20-nor-isopimarane skeleton. Compounds 15–17contain a unique 2-oxabicyclo[2.2.2]octane moiety. Compound 18features an unexpected 2-oxabicyclo[3.2.1]octane moiety. Compounds 8and 12exhibited a moderate inhibitory effect against LPS-induced NO production, with IC50values of 19 and 25 μM, respectively. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 01633864 15206025 |
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| DOI: | 10.1021/acs.jnatprod.3c00893 |