دورية
Bio-efficacy of Olyset®Plus, PermaNet®3.0 and Interceptor®G2 on pyrethroid-resistant populations of Anopheles gambiaes.l. prior to the June 2023 net distribution campaign in Benin, West Africa
| العنوان: | Bio-efficacy of Olyset®Plus, PermaNet®3.0 and Interceptor®G2 on pyrethroid-resistant populations of Anopheles gambiaes.l. prior to the June 2023 net distribution campaign in Benin, West Africa |
|---|---|
| المؤلفون: | Zoungbédji, David Mahouton, Padonou, Germain Gil, Sovi, Arthur, Konkon, Alphonse Keller, Salako, Albert Sourou, Azondékon, Roseric, Sidick, Aboubakar, Ahouandjinou, Juvénal Minassou, Towakinou, Linda, Ossè, Razaki, Aïkpon, Rock, Affoukou, Cyriaque, Baba-Moussa, Lamine, Akogbéto, Martin |
| المصدر: | Tropical Medicine and Health; December 2024, Vol. 52 Issue: 1 |
| مستخلص: | Background: This study investigates the effectiveness of new-generation mosquito nets, like Olyset®Plus and PermaNet®3.0, and dual-action nets such as Interceptor®G2, against pyrethroid-resistant Anopheles gambiaemosquitoes following the 2023 mass distribution of long-lasting insecticidal nets in Benin. Methods: We tested wild mosquito populations from six communes in Benin against various pyrethroid (permethrin 0.75%, alphacypermethrin 0.05%, and deltamethrin 0.05%) using WHO tube tests. Additionally, we exposed mosquitoes to chlorfenapyr 100 µg/ml using the CDC bottle bioassay method. A subset of mosquitoes underwent biochemical and PCR tests to check the overexpression of metabolic enzymes and the Kdr L1014F mutation. We evaluated the effectiveness of Olyset®Plus, PermaNet®3.0, and Interceptor®G2 nets using cone and tunnel tests on both laboratory and field populations of An. gambiae. Results: Overall, the highest mortality rate was 60% with pyrethroid and 98 to100% with chlorfenapyr. In cone tests, all three types of nets induced mortality rates above 80% in the susceptible laboratory strain of An. gambiae. Notably, Olyset®Plus showed the highest mortality rates for pyrethroid-resistant mosquitoes in cone tests, ranging from 81.03% (95% CI: 68.59–90.13) in Djougou to 96.08% (95% CI: 86.54–99.52) in Akpro-Missérété. PermaNet®3.0 had variable rates, from 42.5% (95% CI: 27.04–59.11) in Djougou to 58.54% (95% CI: 42.11–73.68) in Porto-Novo. However, revealed good results for Interceptor®G2, with 94% (95% CI: 87.40–97.77) mortality and 89.09% blood sampling inhibition in local populations of An. gambiae. In comparison, Interceptor®had lower rates of 17% (95% CI: 10.23–25.82) and 60%, respectively. Conclusion: These results suggest that tunnel tests are effective for evaluating dual-active ingredient nets. Additionally, Interceptor®G2 and PBO nets like Olyset®Plus could be considered as alternatives against pyrethroid-resistant mosquitoes. |
| قاعدة البيانات: | Supplemental Index |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 13488945 13494147 |
|---|---|
| DOI: | 10.1186/s41182-024-00599-z |