دورية
Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer
| العنوان: | Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer |
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| المؤلفون: | Castaneda, Carlos A, Flores, Raymundo, Rojas, Katerin Y, Castillo, Miluska, Dolores-Cerna, Ketty, Flores, Claudio, Belmar-Lopez, Carolina, Milla, Esperanza, Gomez, Henry |
| المصدر: | CNS Oncology; May 2015, Vol. 4 Issue: 3 p137-145, 9p |
| مستخلص: | SUMMARY Aim:This retrospective study determined features associated with brain metastasis (BM) in women with breast cancer. Patients & methods:A total of 215 initially early breast cancer cases were included. We reviewed files and CT scan images of BM. Results:Median age was 47 years and most of our cases were stage III (58.6%), grade III (62.8%), ER negative (62.3%) and nonluminal (59.1%). Median survival after BM was 4 months. Nonluminal, extracranial disease, time to CNS shorter than 15 months, >three brain lesions and poor breast-graded prognostic assessment and recursive partitioning analysis scores were associated with shorter survival. Adding extracranial disease to breast-graded prognostic assessment score also predicted survival after BM. Radiation response was assessed in 57 patients and response tended to be associated with nonluminal phenotype but not with survival. Conclusion:Factors associated with both initial tumor and clinical features at BM time are associated with shorter survival in our Latinas population. |
| قاعدة البيانات: | Supplemental Index |
PDF full text from Publisher | تدمد: | 20450907 20450915 |
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| DOI: | 10.2217/cns.15.5 |