التفاصيل البيبلوغرافية
| العنوان: |
Functional constituents of Colchicum lingulatumBoiss. & Spruner subsp. RigescensK. Perss. Extracts and their biological activities with different perspectives |
| المؤلفون: |
Yagi, Sakina, Zengin, Gokhan, Eldahshan, Omayma A., Singab, Abdel Nasser B., Selvi, Selami, Cetiz, Mehmet Veysi, Rodrigues, Maria J., Custodio, Luisa, Dall’Acqua, Stefano, Elhawary, Esraa A. |
| المصدر: |
Food Bioscience; August 2024, Vol. 60 Issue: 1 |
| مستخلص: |
The genus Colchicumcomprises medicinal plants with important bioactive alkaloids, mainly colchicine, and phenolics. The present study was aimed to determine for the first time the phytoconstituents, antioxidant, enzyme inhibition and cytotoxic properties of corms of C. lingulatum. Different solvents extracts (hexane, ethyl acetate, methanol and water) were obtained. The extracts were examined for chemical characterization, antioxidant, enzyme inhibition and cytotoxic properties. To gain more insights, in silicoand network pharmacological analysis were performed. Results of GC/MS analysis of the hexane extract revealed that the extract was dominated by oxygenated diterpenes (37%). UHPLC/MS analysis of ethyl acetate, methanol and aqueous extracts indicated the presence of flavonoids as the most abundant class in addition to phenolic acids and alkaloids. The alkaloid colchicine together with its derivatives colchiceine, colchiciline and isomers were detected in the methanol and aqueous extracts. Results of antioxidant activity showed that the methanol extract exhibited the highest DPPH radical scavenging. At 100 μg/mL, the ethyl acetate, methanol and aqueous extracts displayed potent cytotoxicity against the human embryonic (HEK 293), murine macrophages (RAW 264.7). In silicoanalyzes have investigated the potential of C. lingulatumin cancer therapy using network pharmacology and molecular docking methods. These results demonstrate C. lingulatumcan be a valuable source of bioactive compounds in the development of functional applications including nutraceuticals. |
| قاعدة البيانات: |
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