دورية
Potential Antimalarials. XX. Mannich Base Derivatives of 2-[7-Chloroquinolin-4-ylamino and 7-Bromo(and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]-4-chloro(or 4- or 6-t-Butyl or 4- or 5-fluoro)phenols and 4(or 6)-t-Butyl-2-(7-trifluoromethylquinolin-4-ylamino)phenol
| العنوان: | Potential Antimalarials. XX. Mannich Base Derivatives of 2-[7-Chloroquinolin-4-ylamino and 7-Bromo(and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]-4-chloro(or 4- or 6-t-Butyl or 4- or 5-fluoro)phenols and 4(or 6)-t-Butyl-2-(7-trifluoromethylquinolin-4-ylamino)phenol |
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| المؤلفون: | Bawrlin, GB, Ireland, SJ, Nguyen, TMT, Kotecka, B, Rieckmann, KH |
| المصدر: | Australian Journal of Chemistry; 1994, Vol. 47 Issue: 6 p1143-1154, 12p |
| مستخلص: | Syntheses are reported for some mono- and di-Mannich base derivatives of 4-chloro-, 3- or 4-fluoro-, or 2- or 4-t-butyl-substituted 2-(7′-chloroquinolin-4′-ylamino)phenols and 2-[7′-bromo(and 7′-trifluoromethyl)-1′,5′-naphthyridin-4′-ylamino]phenols. In tests against the FC-27 isolate of Plasmodium falciparum, the most active compound was 2-(7′-chloroquinolin-4′-ylamino)-5-fluoro-4,6-bis(piperidin-1′-ylmethyl)phenol (16) with IC50 12.2 nM. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00049425 14450038 |
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| DOI: | 10.1071/CH9941143 |